Title: Industry-sponsored Symposium: The Effects of Stannous Fluoride on Virulence of Dental Plaque. Novel Learnings (sponsored by P&G Professional Oral Health, Crest+Oral-B)

Bacteria possess a variety of structural or secreted components (so called “virulence factors”) that might cause direct destruction to periodontal tissue or stimulate host cells to activate a wide range of inflammatory responses. These so called Pathogen-associated molecular patterns (PAMPs) include Lipopolysaccharide (LPS), Peptidoglycans (PGNs), Lipoteichoic acid (LTA), Fimbriae, Heat-shock proteins (HSPs), Formyl-methionyl-leucyl-phenylalanine (fMLP), and Proteases (e.g., Gingipains). PAMPs are recognized by Pattern Recognition Receptors (PRRs) present on host cells. PRRs include Toll like receptors (TLR), Nucleotide-binding oligomerization domain proteins (Nod), G-protein-coupled receptors (GPCR) and hBDs. LPS is a cell wall component of gram-negative bacteria with the ability to initiate an inflammatory response. LPS is a PAMP recognized by the host through the TLR 2 and TLR 4. This symposium will focus on the bacteria virulence factors, its interactions with the host receptors and initiation of inflammation. Novel MOA of stannous fluoride including its ability to bind LPS and effect on bacteria metabolism will be discussed.

Learning Objectives:

  • Bacterial virulence factors and their interaction with the host. Speaker Name: Phoebus Madianos
  • Initiation of inflammation – role of phagocytes. Speaker Name: Alpdogan Kantarci
  • The effects of stannous fluoride on plaque virulence Speaker Name: Malgorzata Klukowska