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Title: Dental Oral Craniofacial Tissue Regeneration Consortia: A New Paradigm

This session will be recorded and avaliable in the IADR/ADR Knowledge Community after the meeting. 

The ability to robustly and predictably regenerate dental, oral and craniofacial (DOC) tissues through tissue engineering (TE) and/or regenerative medicine (RM) strategies is a major goal for clinicians. While many technologies have shown proof of principle in small animals, few have made it into the clinic. Many factors contribute the limited translation, including technology development without a clinical context, use of animal models lacking clinical relevance, inability to demonstrate a superior lack of functional outcome against a standard or care, and lack of a large dental and craniofacial presence in the biotech and pharmaceutical industries. To overcome these limitations and develop resources and strategies to advance translation of innovative TE/RM technologies in the DOC space, NIDCR established the DOCTRC Program. This program involves clinicians from the beginning of technology development, and is aimed at developing resources and strategies for regenerating DOC tissues. In 2017, stage II of this program was launched and 2 national Resource Centers (RCs) were established – the Michigan-Pittsburgh-Wyss Resource Center, and the Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR), a consortium of California universities. In this symposium, we will: 1) describe the history of TE/RM and motivation for creating this novel program, 2) describe the structure and function of the 2 RCs, resources available, and how investigators throughout the US in both academia and industry can work with the RCs to advance their technologies through the translational pipeline, 3) discuss significant unmet clinical needs in the DOC space and how to better connect technologies to these unmet needs, and 4) describe some of the technologies currently supported by the RCs

Learning Objectives:

  • Attendees will increase their understanding of how to conduct translational research, how to connect technology to clinical problems and how to connect clinical problems to emerging technologies.
  • Attendees will understand how to access resources of the national Regenerative Medicine Centers to advance translational research
  • Attendees will be provided new knowledge about current novel regenerative medicine research
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