Title: 0882 - Associations of Pain With Quality-of-life in Head and Neck Cancer


María Aguilar (Presenter)
University of Florida

Junad Khan, Eastman Institute for Oral Health
Walter Psoter, Eastman Institute for Oral Health


Objectives: to determine pain associations with quality of life (QOL) domains in head and neck cancer (HNC) patients.

Methods: Consecutive HNC patients of the UF Oral Medicine and ENT clinics were invited to complete a questionnaire that included the Patient Concerns Inventory ( PCI©) and University of Washington Quality of Life (UW-QOLv4) instruments. The PCI© is a clinical questionnaire, which use is recommended by the U.K. National Health Service. The UW-QOLv4 physical and social function domains were dichotomized by lower (worse) vs. upper 3 quartiles as outcomes. The dichotomized domains were then stepwise regressed (logistic model) on the dichotomized PCI© head and neck (HN), and generalized pain items (yes/no), treatment, sex, months since radiation, and treatment modality. The McNemer test was used to assess the relationship of the two pain types

Results: The sample (n=123) means (s.d.) were: age 61.7 (9.9), number of PCI issues 5.3 (5.8), 35% had radiation only, 70% were males. Thirty-four subjects had a positive pain score. 20% (25) had HN and 10% (38) generalized pain with four subjects reporting both pain types (p=0.043). The odds ratios for statistically significant associations with poor physical function were: women 2.7, HN pain 2.9, and 12-months since radiation treatment started 0.29 vs. less-than-12-months. For social function the ORs were: women 0.19, surgery and radiation 7.03, 12-months since radiation 0.3, HN pain 3.22, and generalized pain 6.96.

Conclusions: There is little overlap of pain types in HNC patients. HNC patients reporting HN pain were at a 3-fold increased risk of poor physical and/or social functions; while those reporting generalized pain had a seven-fold increased likelihood of having a social function deficit. Pain should be alert clinicians of the increase potential for a QOL problem and treatment directed toward its mitigation.

This abstract is based on research that was funded entirely or partially by an outside source:
NIH,NIDCR R21 DE019766

Disclosure Statement:
The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONE

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