Title: Immunohistochemical Analysis of VEGF Expression in Condylar Hyperplasia
Seth Butcher (Presenter)
Marquette University - School of Dentistry
Adam Sorenson, Marquette University School of Dentistry
Andrea Doetzer, Pontifícia Universidade Católica do Paraná
Lobat Tayebi, Marquette University School of Dentistry
Carla Loreto, University of Catania
Rosalia Leonardi, Catania University
Morteza Rasoulianboroujeni, Marquette University
Luis Eduardo Almeida, Marquette University
Objectives: The aim of this study was to determine expression levels of vascular endothelial growth factor (VEGF-A) in patients with condylar hyperplasia (CH). CH is a rare disorder characterized by extensive unilateral condylar growth, which results in facial asymmetry with functional and esthetic complications. The etiology of CH is poorly understood, and treatment is usually limited to surgical reduction of affected tissues followed by orthodontic considerations.
Methods: This study used immunohistochemical staining to determine expression levels of VEGF-A in normal condyles and those affected with CH. A total of 17 samples from healthy and affected patients were used. Results were analyzed quantitatively and qualitatively.
Results: Preliminary staining has shown a difference in the expression of VEGF between the control group and the CH group. The experimental group has demonstrated more intense staining with the DAB chromogen than the control group.
Conclusions: We conclude that VEGF expression may be correlated with the development of CH. This study may further clarify the etiology and pathogenesis of CH, leading to improved diagnostic and therapeutic options for those affected.