Toshihisa (Toshi) Kawai received his DDS from Hiroshima University in 1989 and his Ph.D. from Osaka University in 1993. He spent the better part of twenty years conducting research at The Forsyth Institute affiliated with the Harvard School of Dental Medicine where he also taught oral immunology. He has supervised and mentored many dental and graduate students, as well as postdoctoral fellows, toward becoming independent researchers. Marking a major contribution to the field of periodontology, he discovered the induction of RANKL expression by bacteria-reactive T cells, suggesting the possible pathogenic engagement of immune response in periodontal bone resorption. His research projects have been supported by NIH and foundation grants, as well as corporate sponsorships, resulting in more than 100 original research publications. His past postdoctoral fellows and graduate students, all, have obtained faculty positions in academic institutions, and over the past ten years, his research trainees have distinguished themselves with over 40 awards from the researches in his laboratory. In November 2016, he relocated to Nova Southeastern University, College of Dental Medicine (Fort Lauderdale, Florida), where he has found institutional support and resources to broaden and strengthen his research on periodontal pathogenesis from the perspective of osteoimmunology to elucidate the molecular mechanism(s) underlying alveolar bone resorption and retarded bone development, while aiming to develop a noninvasive periodontal bone regeneration therapy. At the AADR Faculty Development Workshop, his talk will address the mindset, strategies and techniques in science writing and grantsmanship, drawing from his own long experience, both sweet and bitter.